Synthesis, Characterization, Investigation of AChE Activities and Molecular Docking Studies of New Schiff Bases Based on Substitute Salicyl Aldehyde

In this study, two new Schiff base compounds (4 and 5) based on substituted salicyl aldehyde were synthesized. The structures of the synthesized determined by FT-IR 1H(13C) NMR spectroscopies. AChE inhibition activities investigated. According to results obtained, 4 (IC50: 1.396 ± 0.35 ?M) 5 0.795 0.47?M) found be significantly effective than Tacrin (TAC) 166.10 17.53 (currently used drug). interaction types binding energies compound 5, which has higher activity, investigated molecular docking studies.